Although erectile dysfunction ED is not life-threatening, it is a severe psychological and physiological problem. Many studies have proven the connection between the quality of intimate life and general health and even life expectancy.
PDE5 inhibitors (sildenafil citrate (Viagra), vardenafil (Levitra), and tadalafil (Cialis)) are the first-line treatment for ED. These erection modulators have the same mechanism of action. The drugs do not cause an erection directly but enhance the relaxing effect of NO through cGMP. Physiological erection occurs as a result of increased blood flow in the corpora cavernosa of the penis. In the absence of sexual stimulation, PDE5 inhibitors have no effect.
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Cialis is the FDA-approved medication for treating ED and benign prostatic hyperplasia. This is the only oral drug that improves potency for up to 36 hours. Cialis is currently available in more than 60 countries, including Australia, Brazil, Mexico, Canada, and the United States.
The main properties and advantages:
Patients taking the drug note a rapid improvement in sexual function and self-confidence. In addition, sexual relationships become more natural and emotionally rich.
Erection is a neurovascular process characterized by enhanced blood supply to the corpora cavernosa under the influence of neural and humoral mechanisms occurring at various levels of the nervous system. Sexual stimulation causes the release of relaxing neurotransmitters from the nerve endings and penile endothelial cells. This helps to relax the smooth muscles and arterioles supplying the corpora cavernosa.
Relaxation of trabecular smooth muscle leads to rapid blood filling. The cavernous spaces expand. The superficial subtunicular plexus between the trabeculae and the tunica albuginea becomes compressed, resulting in almost complete blockage of the venous outflow.
It should be noted that passive cessation of outflow through the deep vein is because it does not have structures that protect it from compression within the resulting area of increased blood pressure. An erection occurs when the volume of blood inside the penis increases several times.
Erectile dysfunction is the inability to achieve or maintain an erection sufficient for full sexual intercourse. The severity of this disorder ranges from temporary and mild episodes to persistent and severe erection problems. However, in any case, ED can cause physical and emotional issues, including decreased self-esteem/confidence and increased stress levels. Moreover, ED can negatively affect a partner by creating misunderstandings in the relationship and reducing intimacy. So, erectile dysfunction is a serious medical condition that requires attention and timely treatment.
ED can be psychogenic or organic in origin. Anxiety, lack of sexual arousal, and the presence of mental illness such as depression are the most common psychogenic causes. As for organic reasons, the list is much wider. Thus, common neurological conditions that trigger the development of ED include Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, ischemic or hemorrhagic stroke, spinal lesions, and traumatic brain injury.
Vascular arterial disorders that cause ED are very diverse. These are arterial hypertension, hyperlipidemia, diabetic microangiopathy, irradiation of the pelvic area and associated arterial damage.
Hormonal causes of erectile dysfunction may be associated with a lack of certain hormones or with their excess in the body. For example, low levels of testosterone (the main male sex hormone) can lead to decreased libido, affect the quality and duration of erections. Erectile function can also be affected by hormonal changes associated with age or endocrine dysfunction. Possible causes include diabetes, thyroid disorders, hyperprolactinemia, etc.
According to research, smokers suffer from ED more often than non-smokers. This is due to vasoconstriction and increased venous outflow.
You can easily buy Cialis without prescription today. Our service offers a wide selection of high-quality drugs 24/7. All you need to do is select the appropriate medicine and place your order. You can give preference to a brand ED medication or order generic Cialis online. The generic contains the same active ingredient as the original, but the price is usually cheaper.
Even though you can buy Cialis no prescription, we still recommend visiting a doctor before starting treatment. It won’t take much time, but you will find out whether Cialis is really good in your case.
As mentioned above, Cialis helps with ED and benign prostatic hyperplasia. Read the following paragraphs and learn more about its mechanism of action.
Tadalafil is effective in treating ED. It is based on the physiological mechanisms underlying erection. When NO levels in penile smooth muscle tissue increase in response to sexual stimulation, PDE5 inhibition causes a rise in cGMP concentrations in the glans penis, corpus cavernosum, and corpus spongiosum. As a result, smooth muscles relax and erection improves. PDE5 inhibitor does not have an erectogenic effect on the penis in the absence of sexual stimulation when the concentration of nitric oxide and cGMP is low.
PDE 5 inhibitor therapy is considered fairly safe for the vast majority of men. Side effects (hypersensitivity reactions, nasal congestion, dyspepsia, headache, tachycardia, etc.) in most cases are mild and short-term.
You can also buy generic Cialis to get rid of the unpleasant symptoms of benign prostatic hyperplasia, such as a weak urine stream, constant urge to urinate, burning sensation in the urethra, feeling of incomplete bladder emptying, cloudy urine, frequent urination at night, etc.
Research data published in the 2016 EAU GuideLines show that Cialis tadalafil 5 mg provides rapid and significant symptom relief in patients with BPH when used daily. The effectiveness of the drug is similar to alpha1-blockers. An increase in intracellular cyclic guanosine monophosphate reduces the smooth muscle tone of the detrusor, prostate, and urethra. In addition, PDE5 inhibitors increase blood supply and oxygenation of the lower urinary tract, as well as reduce chronic inflammation in the prostate and bladder.
Off-label uses include pulmonary arterial hypertension and Raynaud’s syndrome. The drug also helps support the sexual health of men receiving antidepressant therapy. In addition, Cialis is a good cardio-protective agent.
Cialis is for oral use. The recommended dose is 10 mg 16-30 minutes before anticipated sexual activity, regardless of food intake. If tadalafil 10 mg does not produce the desired effect, you can try 20 mg. The maximum recommended frequency of administration is 1 time per day. Patients may attempt sexual intercourse at any time within 36 hours after taking the drug.
Daily use of the drug requires lower doses. We recommend taking Cialis 5 mg at approximately the same time. The dose can be reduced to 2.5 mg per day based on individual tolerability of the drug.
Men with benign prostatic hyperplasia should take Cialis tadalafil 5 mg daily during the treatment cycle. In this case, it is not advisable to use a 10 or 20 mg dose as needed.
Like any other medication, Cialis has alternatives. Viagra and Levitra are the most popular today. The main features are reviewed in detail below.
Just like Cialis, Viagra is a selective PDE5 inhibitor. The drug contains the active ingredient sildenafil. It has a favorable pharmacokinetic profile and is rapidly absorbed after oral administration, reaching peak plasma concentrations within 30-120 minutes. Main advantages: high efficiency, reliability, ease of use, minimal side effects.
It is recommended to take Viagra once a day, 1 hour before intended sexual intercourse. The average dose is 50 mg, but it may vary depending on effect and tolerability.
The action begins 40-60 minutes after administration, although, according to recent studies, many patients notice the effect within 14 minutes. It lasts for 3–5 hours. Fatty foods and alcohol reduce the drug’s effectiveness.
Levitra vardenafil is another good option you can use to treat impaired sexual function. It is absorbed more quickly than other PDE5 inhibitors, so the effect occurs within 10-25 minutes after oral administration. The duration of action is 8-12 hours. Eating and drinking alcohol does not affect effectiveness.
The medication is available in three doses (5, 10, 20 mg). The starting dose is 10 mg. The maximum recommended frequency of use is 1 time per day. Depending on effectiveness and tolerability, the dose may be increased to 20 mg.
Vardenafil is highly effective in treating patients with multiple cardiovascular risk factors, such as diabetes mellitus, hyperlipidemia, and hypertension.
Erectile dysfunction is one of the most common sexual disorders today. It requires timely diagnosis and treatment. PDE5 drugs, such as Cialis, are effective in treating most patients, regardless of the ED cause, age, concomitant diseases, etc.
You can buy tadalafil online without any restrictions and start treatment right away. But it is still recommended to consult a doctor and find out about the advisability of using this medication in order to prevent side reactions.
Cialis is not suitable for people with hypersensitivity to tadalafil. Doctors do not allow taking the drug simultaneously with organic nitrates in any dosage form. Men with heart disease and contraindications to sexual activity should also avoid using Cialis.
You can break Cialis in half if you need a smaller dosage.
Cialis is an effective drug for treating ED and BPH, but there is no evidence that it is safe for healthy men. Therefore, you should not take Cialis without ED, so as not to provoke negative reactions in the body.
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